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The Praxis Chemistry (5246) exam is designed for aspiring chemistry teachers and evaluates your knowledge of key chemistry concepts, including atomic theory, chemical reactions, thermodynamics, and laboratory techniques. The exam tests your ability to apply chemistry principles to real-world situations, as well as your understanding of scientific inquiry and problem-solving skills. Our expert study resources, practice tests, and detailed explanations will help you build a solid foundation in chemistry, ensuring you're fully prepared to pass the exam and begin your teaching career with confidence.
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- Praxis Chemistry (5246)
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Praxis Chemistry (5246) Practice Test
The Praxis® Chemistry: Content Knowledge (5246) exam is designed to measure the chemistry knowledge and teaching competencies required for safe and effective beginning practice as a secondary-level chemistry teacher. Test takers typically have completed a bachelor’s degree with appropriate coursework in chemistry and education.
Prepare for your Praxis Chemistry: Content Knowledge (5246) exam with our comprehensive practice test questions, expert study tips, and exam-focused resources designed to help you succeed. At Prepsaret, we offer free practice tests, study guides, and flashcards to help aspiring chemistry teachers perform at their best on test day.
Praxis Chemistry (5246) Exam Test Format and Structure
The Praxis Chemistry exam contains 125 selected-response questions and four constructed-response questions, and you will be given a time limit of 2.5 hours.
Basic Test Information
- Test Name: Chemistry
- Test Code: 5246
- Number of Questions: 125 selected-response questions
- Time Limit: 2 hours 30 minutes
- Test Format: Computer-delivered
- Question Types: Selected-response questions (including questions with one or more correct answers)
- Calculator Use: Not permitted
- Reference Materials: Periodic table, physical constants, and select SI unit conversions provided on-screen
Half or more of the questions integrate Science and Engineering Practices (SEPs), and approximately one-quarter to one-third of the questions assess chemistry content applied to Tasks of Teaching Science.

Praxis Chemistry (5246) Scoring Information
The Praxis® Chemistry exam uses a scaled scoring system. Your score is based on the number of questions answered correctly (raw score), which is then converted to a scaled score. Passing score requirements vary by state, so be sure to check with your state’s education department.
- Exam Fee: $130
- Unofficial Scores: Available at the test center for most candidates
- Official Score Reports: Typically available within five weeks after testing
Some questions on the exam may be unscored and do not count toward your final score.
Praxis Chemistry (5246) Exam Outline
The Praxis® Chemistry exam is divided into five content categories, reflecting national and state standards, including the Next Generation Science Standards (NGSS) and the National Science Teaching Association (NSTA) Preparation Standards.
I. Nature and Impact of Science and Engineering (17 questions – 14%)
The questions in this category assess your knowledge of:
- Nature of science
- Science, engineering, technology, society, and the environment
II. Principles and Models of Matter and Energy (31 questions – 25%)
The questions in this category assess your knowledge of:
- Atomic and nuclear structure and processes
- Relationships between energy and matter in chemistry
III. Chemical Composition, Bonding, and Structure (25 questions – 20%)
The questions in this category assess your knowledge of:
- Chemical composition
- Chemical bonding and molecular structure
IV. Chemical Reactions and Periodicity (29 questions – 23%)
The questions in this category assess your knowledge of:
- Periodic trends
- Fundamental principles of chemical reactions
V. Solutions and Acid-Base Chemistry (23 questions – 18%)
The questions in this category assess your knowledge of:
- Solutions and solubility
- Acid-base chemistry

Free Praxis® Chemistry (5246) Practice Test
Start preparing today with our free Praxis® Chemistry practice test. This diagnostic tool helps you assess your current knowledge, identify weak areas, and focus your study time where it matters most.
Additional Resources
Study Guide
Dive deeper into key chemistry concepts with our comprehensive Praxis Chemistry Study Guide, featuring detailed explanations and exam-aligned content.
Flashcards
Reinforce complex topics with our Praxis® Chemistry Flashcards, designed to break down challenging material into easy-to-understand concepts.
Online Course
Explore our interactive online course with video lessons, quizzes, and targeted practice to help you master both chemistry content and teaching applications.
Why Choose Prepsaret?
At Prepsaret, we’re committed to helping future educators succeed. Our Praxis® Chemistry prep resources are designed to:
- Simplify complex chemistry concepts
- Provide realistic practice questions with detailed explanations
- Integrate content knowledge with Science and Engineering Practices
- Build confidence for both content mastery and teaching scenarios
Our materials are developed by experienced educators and subject-matter experts to ensure alignment with current standards and real classroom expectations.
Get Started Today
Take the next step toward becoming a certified chemistry teacher. Begin with our free Praxis Chemistry practice test, then strengthen your preparation with our study guides and flashcards.
Prepsaret is not affiliated with or endorsed by the Educational Testing Service (ETS). All organizational and test names are trademarks of their respective owners.
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FAQs About Praxis Chemistry
The Praxis Chemistry: Content Knowledge (5246) exam measures the chemistry knowledge and teaching skills needed to teach chemistry at the secondary level.
The exam consists of 125 selected-response questions.
You have 2 hours and 30 minutes to complete the exam.
Passing scores vary by state. Check with your state’s education department for specific requirements.
The examination fee is $130.
To register, create an online ETS account, choose your test format (remote or in-person), select a test date and location, and pay the exam fee.
Yes. ETS offers a remote testing option using the Secure Test Browser, along with webcam and microphone monitoring by a live proctor.
Official score reports are typically available about five weeks after your test date.