During meiosis, homologous chromosomes pair up until the time comes to separate and become a sex cell. If this process does not occur correctly, then the sperm or eggs can have the incorrect number of chromosomes. To avoid mistakes happening during meiosis, many chromosomes stick together in a process called crossing over. Researchers found that a thin strand of DNA appears to bind the homologous chromosomes together. However, they could not figure out how they came back apart when meiosis was over. They conducted further research on fruit flies and discovered that when an enzyme called topoisomerase II was inactivated, the chromosomes were unable to come apart. The result was that the fruit flies were sterile.
Based on the passage, what is the relationship between topoisomerase II and meiosis?
The correct answer is: Topoisomerase II helps to separate chromosomes after meiosis.
The passage states that when topoisomerase II was inactivated in fruit flies, "the chromosomes were unable to come apart." This directly implies that topoisomerase II is responsible for separating chromosomes after meiosis. The researchers' discovery that inactivating this enzyme led to sterility in fruit flies further supports this conclusion, as proper chromosome separation is crucial for successful meiosis and fertility.
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